If they disappear, you know you can move on. From this point onward, Mr X can appear as you explore - hear out for the footsteps to know he's nearby, and if they grow loud, look at the closest door. Wait until his footsteps disappear, so you know he's gone - for now. As Leon this is the Boiler Room, and as Claire this is the Chief's Office. On your first encounter, turn tail and run back to the nearest safe room - also known as areas with an Item Box and / or a Typewriter - where no enemies, including Mr X, can harm you. Though you can pump Mr X full of ammo to temporarily down him, the best way to deal with him is avoidance. PS5/ Xbox Series X/S - Resident Evil 2 Remake/ Resident Evil 3 Remake analysis How to survive Mr X encounters Looking for something else? Visit our Resident Evil 2 walkthrough for more help. You'll encounter Mr X shortly after you find the Club Key and Heart Key as Leon and Claire respectively. If you didn't play the original Resident Evil 2, Mr X is an indestructible enemy that will stalk you around the Police Station in the game's B Scenarios - but now he appears in the main story, which is bad news for us. Resident Evil 2's Mr X is one of the game's best and most terrifying moments.